Absence of Tumor-Infiltrating Lymphocyte Is a Reproducible Predictive Factor for Sentinel Lymph Node Metastasis: A Multicenter Database Study by the Brazilian Melanoma Group
Identifieur interne : 001481 ( Main/Exploration ); précédent : 001480; suivant : 001482Absence of Tumor-Infiltrating Lymphocyte Is a Reproducible Predictive Factor for Sentinel Lymph Node Metastasis: A Multicenter Database Study by the Brazilian Melanoma Group
Auteurs : João Pedreira Duprat [Brésil] ; Eduard René Brechtbülh [Brésil] ; Bianca Costa De Sá [Brésil] ; Mauro Enokihara [Brésil] ; Jose Humberto Fregnani [Brésil] ; Gilles Landman [Brésil] ; Marcus Maia [Brésil] ; Felice Riccardi [Brésil] ; Francisco Alberto Belfort [Brésil] ; Alberto Wainstein [Brésil] ; Luciana F. Moredo [Brésil] ; Higino Steck [Brésil] ; Miguel Brandão [Brésil] ; Marcelo Moreno [Brésil] ; Eduardo Miranda [Brésil] ; Ivan Dunshee De Oliveira Santos [Brésil]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
The aim of this study is to confirm the function of tumor-infiltrating lymphocytes (TILs) in sentinel lymph node (SLN) metastasis.
This retrospective study included 633 patients with invasive melanoma who underwent sentinel lymph node biopsy in 7 referral centers certified by the Brazilian Melanoma Group. Independent risk factors of sentinel node metastasis (SNL) were identified by multiple logistic regression.
SLN metastasis was detected in 101 of 633 cases (16.1%) and in 93 of 428 patients (21.7%) when melanomas ≤ 1mm were excluded. By multiple logistic regression, the absence of TILs was as an independent risk factor of SLN metastasis (OR = 1.8; 95%CI: 1.1–3.0), in addition to Breslow index (greater than 2.00 mm), lymph vascular invasion, and presence of mitosis.
SLNB can identify patients who might benefit from immunotherapy, and the determination of predictors of SLNB positivity can help select the proper population for this type of therapy. The absence of TILs is a reproducible parameter that can predict SLNB positivity in melanoma patients, since this study was made with several centers with different dermatopathologists.
Url:
DOI: 10.1371/journal.pone.0148160
PubMed: 26859408
PubMed Central: 4747578
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Absence of Tumor-Infiltrating Lymphocyte Is a Reproducible Predictive Factor for Sentinel Lymph Node Metastasis: A Multicenter Database Study by the Brazilian Melanoma Group</title><author><name sortKey="Duprat, Joao Pedreira" sort="Duprat, Joao Pedreira" uniqKey="Duprat J" first="João Pedreira" last="Duprat">João Pedreira Duprat</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>AC Camargo Cancer Center, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>AC Camargo Cancer Center, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Brechtbulh, Eduard Rene" sort="Brechtbulh, Eduard Rene" uniqKey="Brechtbulh E" first="Eduard René" last="Brechtbülh">Eduard René Brechtbülh</name><affiliation wicri:level="3"><nlm:aff 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type="main">Absence of Tumor-Infiltrating Lymphocyte Is a Reproducible Predictive Factor for Sentinel Lymph Node Metastasis: A Multicenter Database Study by the Brazilian Melanoma Group</title><author><name sortKey="Duprat, Joao Pedreira" sort="Duprat, Joao Pedreira" uniqKey="Duprat J" first="João Pedreira" last="Duprat">João Pedreira Duprat</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>AC Camargo Cancer Center, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>AC Camargo Cancer Center, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Brechtbulh, Eduard Rene" sort="Brechtbulh, Eduard Rene" uniqKey="Brechtbulh E" first="Eduard René" last="Brechtbülh">Eduard René Brechtbülh</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>AC Camargo Cancer Center, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>AC Camargo Cancer Center, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Costa De Sa, Bianca" sort="Costa De Sa, Bianca" uniqKey="Costa De Sa B" first="Bianca" last="Costa De Sá">Bianca Costa De Sá</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>AC Camargo Cancer Center, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>AC Camargo Cancer Center, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Enokihara, Mauro" sort="Enokihara, Mauro" uniqKey="Enokihara M" first="Mauro" last="Enokihara">Mauro Enokihara</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Medical School, São Paulo Federal University, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Medical School, São Paulo Federal University, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Fregnani, Jose Humberto" sort="Fregnani, Jose Humberto" uniqKey="Fregnani J" first="Jose Humberto" last="Fregnani">Jose Humberto Fregnani</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Barretos Cancer Hospital, Barretos, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Barretos Cancer Hospital, Barretos</wicri:regionArea><wicri:noRegion>Barretos</wicri:noRegion></affiliation></author><author><name sortKey="Landman, Gilles" sort="Landman, Gilles" uniqKey="Landman G" first="Gilles" last="Landman">Gilles Landman</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Medical School, São Paulo Federal University, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Medical School, São Paulo Federal University, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Maia, Marcus" sort="Maia, Marcus" uniqKey="Maia M" first="Marcus" last="Maia">Marcus Maia</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Santa Casa de Misericórdia, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Santa Casa de Misericórdia, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Riccardi, Felice" sort="Riccardi, Felice" uniqKey="Riccardi F" first="Felice" last="Riccardi">Felice Riccardi</name><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Santa Rita Hospital, Porto Alegre, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Santa Rita Hospital, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Belfort, Francisco Alberto" sort="Belfort, Francisco Alberto" uniqKey="Belfort F" first="Francisco Alberto" last="Belfort">Francisco Alberto Belfort</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Sirio Libanês Hospital, Oswaldo Cruz Hospital, São José Hospital, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sirio Libanês Hospital, Oswaldo Cruz Hospital, São José Hospital, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Wainstein, Alberto" sort="Wainstein, Alberto" uniqKey="Wainstein A" first="Alberto" last="Wainstein">Alberto Wainstein</name><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Minas Gerais School of Medicine, Belo Horizonte, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Minas Gerais School of Medicine, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region></placeName></affiliation></author><author><name sortKey="Moredo, Luciana F" sort="Moredo, Luciana F" uniqKey="Moredo L" first="Luciana F." last="Moredo">Luciana F. Moredo</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>AC Camargo Cancer Center, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>AC Camargo Cancer Center, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Steck, Higino" sort="Steck, Higino" uniqKey="Steck H" first="Higino" last="Steck">Higino Steck</name><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Mario Gatti Hospital, Campinas, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Mario Gatti Hospital, Campinas</wicri:regionArea><wicri:noRegion>Campinas</wicri:noRegion></affiliation></author><author><name sortKey="Brandao, Miguel" sort="Brandao, Miguel" uniqKey="Brandao M" first="Miguel" last="Brandão">Miguel Brandão</name><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>AMO Clinic, Salvador, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>AMO Clinic, Salvador</wicri:regionArea><wicri:noRegion>Salvador</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Marcelo" sort="Moreno, Marcelo" uniqKey="Moreno M" first="Marcelo" last="Moreno">Marcelo Moreno</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Medical School, Community University of Chapecó Region, Chapecó, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Medical School, Community University of Chapecó Region, Chapecó</wicri:regionArea><wicri:noRegion>Chapecó</wicri:noRegion></affiliation></author><author><name sortKey="Miranda, Eduardo" sort="Miranda, Eduardo" uniqKey="Miranda E" first="Eduardo" last="Miranda">Eduardo Miranda</name><affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Oncology Department, Pernambuco University, Recife, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Oncology Department, Pernambuco University, Recife</wicri:regionArea><wicri:noRegion>Recife</wicri:noRegion></affiliation></author><author><name sortKey="Santos, Ivan Dunshee De Oliveira" sort="Santos, Ivan Dunshee De Oliveira" uniqKey="Santos I" first="Ivan Dunshee De Oliveira" last="Santos">Ivan Dunshee De Oliveira Santos</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Medical School, São Paulo Federal University, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Medical School, São Paulo Federal University, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Aims</title><p>The aim of this study is to confirm the function of tumor-infiltrating lymphocytes (TILs) in sentinel lymph node (SLN) metastasis.</p></sec><sec id="sec002"><title>Materials and Methods</title><p>This retrospective study included 633 patients with invasive melanoma who underwent sentinel lymph node biopsy in 7 referral centers certified by the Brazilian Melanoma Group. Independent risk factors of sentinel node metastasis (SNL) were identified by multiple logistic regression.</p></sec><sec id="sec003"><title>Results</title><p>SLN metastasis was detected in 101 of 633 cases (16.1%) and in 93 of 428 patients (21.7%) when melanomas ≤ 1mm were excluded. By multiple logistic regression, the absence of TILs was as an independent risk factor of SLN metastasis (OR = 1.8; 95%CI: 1.1–3.0), in addition to Breslow index (greater than 2.00 mm), lymph vascular invasion, and presence of mitosis.</p></sec><sec id="sec004"><title>Conclusion</title><p>SLNB can identify patients who might benefit from immunotherapy, and the determination of predictors of SLNB positivity can help select the proper population for this type of therapy. The absence of TILs is a reproducible parameter that can predict SLNB positivity in melanoma patients, since this study was made with several centers with different dermatopathologists.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wong, Sl" uniqKey="Wong S">SL Wong</name></author><author><name sortKey="Balch, Cm" uniqKey="Balch C">CM Balch</name></author><author><name sortKey="Hurley, P" uniqKey="Hurley P">P Hurley</name></author><author><name sortKey="Agarwala, Ss" uniqKey="Agarwala S">SS Agarwala</name></author><author><name sortKey="Akhurst, Tj" uniqKey="Akhurst T">TJ Akhurst</name></author><author><name sortKey="Cochran, A" uniqKey="Cochran A">A Cochran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garbe, C" uniqKey="Garbe C">C Garbe</name></author><author><name sortKey="Schadendorf, D" uniqKey="Schadendorf D">D Schadendorf</name></author><author><name sortKey="Stolz, W" 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Brady</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Minas Gerais</li><li>Rio Grande do Sul</li><li>État de São Paulo</li></region><settlement><li>Belo Horizonte</li><li>Porto Alegre</li><li>São Paulo</li></settlement></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Duprat, Joao Pedreira" sort="Duprat, Joao Pedreira" uniqKey="Duprat J" first="João Pedreira" last="Duprat">João Pedreira Duprat</name></region><name sortKey="Belfort, Francisco Alberto" sort="Belfort, Francisco Alberto" uniqKey="Belfort F" first="Francisco Alberto" last="Belfort">Francisco Alberto Belfort</name><name sortKey="Brandao, Miguel" sort="Brandao, Miguel" uniqKey="Brandao M" first="Miguel" last="Brandão">Miguel Brandão</name><name sortKey="Brechtbulh, Eduard Rene" sort="Brechtbulh, Eduard Rene" uniqKey="Brechtbulh E" first="Eduard René" last="Brechtbülh">Eduard René Brechtbülh</name><name sortKey="Costa De Sa, Bianca" sort="Costa De Sa, Bianca" uniqKey="Costa De Sa B" first="Bianca" last="Costa De Sá">Bianca Costa De Sá</name><name sortKey="Enokihara, Mauro" sort="Enokihara, Mauro" uniqKey="Enokihara M" first="Mauro" last="Enokihara">Mauro Enokihara</name><name sortKey="Fregnani, Jose Humberto" sort="Fregnani, Jose Humberto" uniqKey="Fregnani J" first="Jose Humberto" last="Fregnani">Jose Humberto Fregnani</name><name sortKey="Landman, Gilles" sort="Landman, Gilles" uniqKey="Landman G" first="Gilles" last="Landman">Gilles Landman</name><name sortKey="Maia, Marcus" sort="Maia, Marcus" uniqKey="Maia M" first="Marcus" last="Maia">Marcus Maia</name><name sortKey="Miranda, Eduardo" sort="Miranda, Eduardo" uniqKey="Miranda E" first="Eduardo" last="Miranda">Eduardo Miranda</name><name sortKey="Moredo, Luciana F" sort="Moredo, Luciana F" uniqKey="Moredo L" first="Luciana F." last="Moredo">Luciana F. Moredo</name><name sortKey="Moreno, Marcelo" sort="Moreno, Marcelo" uniqKey="Moreno M" first="Marcelo" last="Moreno">Marcelo Moreno</name><name sortKey="Riccardi, Felice" sort="Riccardi, Felice" uniqKey="Riccardi F" first="Felice" last="Riccardi">Felice Riccardi</name><name sortKey="Santos, Ivan Dunshee De Oliveira" sort="Santos, Ivan Dunshee De Oliveira" uniqKey="Santos I" first="Ivan Dunshee De Oliveira" last="Santos">Ivan Dunshee De Oliveira Santos</name><name sortKey="Steck, Higino" sort="Steck, Higino" uniqKey="Steck H" first="Higino" last="Steck">Higino Steck</name><name sortKey="Wainstein, Alberto" sort="Wainstein, Alberto" uniqKey="Wainstein A" first="Alberto" last="Wainstein">Alberto Wainstein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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